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Volume 42 Issue 5
May  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(5): 1185-1191

Selection strategies and future perspectives for animal models of gastroesophageal varices

DOI: 10.12449/JCH260527
  • 1.

    Department of Gastroenterology，The First Affiliated Hospital of Kunming Medical University/Yunnan Institute of Digestive Diseases/Yunnan Province Clinical Research Center for Digestive Diseases，Kunming 650032，China

  • 2.

    Department of General Practice，The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology，Kunming 650057，China

Research funding:

Joint Medical Research Program of Kunming University of Science and Technology and the First People's Hospital of Yunnan Province (KUST-KH2022035Y)

More Information
  • Corresponding author: LU Bingtuan， lbtyfgx@163.com （ORCID： 0009-0004-7874-8024）
  • Received Date: 2025-09-25
  • Accepted Date: 2025-12-02
  • Published Date: 2026-05-25
    Abstract
  • Gastroesophageal varices （GOV） bleeding is a severe complication of portal hypertension with a high mortality rate. Animal models are indispensable tools for investigating its pathogenesis and developing novel therapeutic strategies. This article systematically reviews the methods for establishing various GOV models， with a particular focus on their efficacy in simulating the key pathological processes such as an increase in hepatic venous pressure gradient and the risk of bleeding， and it also proposes targeted strategies for model selection. Finally， this article discusses the application prospects of emerging techniques in the era of precision medicine， such as organoids and gene editing， in order to provide model selection and a theoretical reference for exploring the mechanism and clinical translation of GOV.

     

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