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Volume 42 Issue 2
Feb.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(2): 438-444

Mechanism of action of estrogen deficiency in autoimmune hepatitis via the intestinal barrier

DOI: 10.12449/JCH260226
  • 1.

    Third Ward of Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • 2.

    Department of Liver Diseases，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China

  • 3.

    Encephalopathy Center，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

Research funding:

Natural Science Foundation of Henan Province (222300420490);

Joint Fund Project of Henan Provincial R&D Program (222301420069);

Henan TCM Double First-Class Research Grant in 2023 (HSRP-DFCTCM-2023-7-24);

Henan Health Commission TCM Innovation Center Grant in 2023 (2023ZXZX1129)

More Information
  • Corresponding author: LIU Guangwei， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）
  • Received Date: 2025-06-28
  • Accepted Date: 2025-09-29
  • Published Date: 2026-02-25
    Abstract
  • Autoimmune hepatitis （AIH） is an immune-mediated chronic liver inflammatory disease with unknown pathogenesis， and intestinal barrier dysfunction is considered an important factor. Meanwhile， there are sex and age differences in the incidence rate of AIH， suggesting that hormone may be involved in regulation. On this basis， this article focuses on the association between estrogen， intestinal barrier， and immune homeostasis， systematically reviews the evidence that estrogen deficiency disrupts intestinal barrier homeostasis， and further summarizes the potential mechanism of estrogen in regulating the development and progression of AIH via intestinal barrier.

     

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