Clinical features of patients with recurrent primary common bile duct stones after cholecystectomy

Jianhui LU; Yongli LI; Ruifang GUO; Rongquan XUE

doi:10.12449/JCH250118

Volume 41 Issue 1

Jan. 2025

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Clinical features of patients with recurrent primary common bile duct stones after cholecystectomy

DOI: 10.12449/JCH250118

Jianhui LU^1a,
Yongli LI²,
Ruifang GUO^{1a
,
,
,},
Rongquan XUE^{1b
,
,
,}

1a.
Clinical Nutrition Center Pancreatic and Spleen Surgery，Inner Mongolia People’s Hospital, Hohhot 010017，China
1b.
Department of Hepatobiliary，Pancreatic and Spleen Surgery，Inner Mongolia People’s Hospital, Hohhot 010017，China
2.
Inner Mongolia Clinical College，Inner Mongolia Medical University，Hohhot 010059，China

Research funding:

Inner Mongolia Academy of Medical Sciences Public Hospital Research Joint Fund Project (2023GLLH0021);

Science and Technology Project of Inner Mongolia Autonomous Region (2021GG0116);

Natural Science Foundation Project of Inner Mongolia Autonomous (2019MS08086)

More Information

Corresponding author: GUO Ruifang， 6872_grf@163.com （ORCID： 0000-0002-0756-3549）; XUE Rongquan， xrq1212@189.com （ORCID： 0009-0003-9411-8121）
Received Date: 2024-06-14
Accepted Date: 2024-07-31
Published Date: 2025-01-25

Abstract

Abstract

Objective To investigate the general situation， dietary factors， and clinical features of patients with recurrent primary common bile duct stones， and to provide a basis for effective prevention of stone recurrence. Methods A retrospective analysis was performed for 23 730 patients who underwent cholecystectomy due to cholelithiasis in Department of Hepatobiliary， Pancreatic and Spleen Surgery， Inner Mongolia People’s Hospital， from January 2013 to December 2023， and according to the presence or absence of recurrence of primary common bile duct stones after surgery， 334 patients were divided into recurrence group. The recurrence group was further analyzed based on sex in terms of recurrence rate， recurrence cycle， recurrence age， recurrence type， and general， disease， imaging， and dietary factors. The independent-samples t test was used for comparison of continuous data between two groups， the chi-square test was used for comparison of categorical data between two groups. Results There were 334 cases of recurrence of primary bile duct stones after cholecystectomy， with a recurrence rate of 1.41%， and the highest frequency of recurrence cycle was observed in 10 years after surgery， with a significant difference in recurrence cycle between the male and female patients （t=5.238， P<0.001）. There was a significant difference in the recurrence rate of stones after surgery between the patients with simple gallstones and those with gallbladder and common bile duct stones at initial diagnosis （1.23% vs 2.76%， χ²=42.104， P<0.001）. The patients with recurrence aged >60 years accounted for the highest proportion in the whole population and in both male and female populations， and 92% were Han residents； 10% of the patients with recurrence had a family history of gallstones， and as for comorbidities， the patients with hypertension accounted for the highest proportion. Among the patients with recurrence， the patients with smoking or drinking accounted for 76.7% and 10.3%， respectively. As for body weight， 63.8% of the patients with recurrence had a normal body mass index （BMI）， and 23.2% of the patients were overweight； compared with body weight at the time of the first gallbladder surgery， a reduction in body weight was observed in 60.1% of the patients with recurrence， while an increase in body weight was observed in 22.9% of the patients with recurrence. There were significant differences between the male and female patients with recurrence in age composition， ethnicity， the type of place of residence， comorbidities， smoking， drinking， BMI， and the change in body weight （all P<0.001）. As for the type of stone recurrence， the ratio of multiple stones， solitary stones， and muddy stones was 74∶15∶11， and the stone size of <1 cm， 1-2 cm， and >2 cm accounted for about 40.5%， 48.8%， and 10.6%， respectively. As for the surgical procedure， the patients undergoing laparotomy accounted for 66.1%， and those undergoing laparoscopy accounted for 33.9%. The patients with various types of dyslipidemia accounted for a percentage of<30%. There were significant differences between the male and female patients with recurrence in the type of stones at initial onset， the type and size of stones， and surgical procedure （all P<0.001）. Imaging data showed that 4 patients had an abnormal structure of the bile duct， manifesting as long and curve cystic ducts， and 73.1% of the patients had common bile duct dilatation after surgery. The follow-up of dietary factors showed irregular diets in 55.8% of the patients with recurrence. As for the dietary structure， meat and staple food accounted for 43.8% and 37.8%， respectively， which showed a sex difference， with meat in male patients and staple food in female patients； 64.1% of the patients with recurrence had a high-salt and high-oil diet； 59.8% of the patients had changes in diet after the first surgery for stones， among whom 80% were able to have a regular diet， and the patients with a regular diet accounted for 92%. Conclusion There is a relatively low recurrence rate of primary common bile duct stones in this area， and there is no sex difference. The peak of recurrence is 10 years after surgery， and recurrence of stones is mainly observed in the population aged >60 years. The analysis of dietary and clinical features can help doctors and patients to further understand the characteristics of the recurrence of primary common bile duct stones and provide a basis for subsequent targeted prevention.
- Cholecystectomy,
- Choledocholithiasis,
- Recurrence,
- Pathological Conditions， Signs and Symptoms

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References(39)

References

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Clinical features of patients with recurrent primary common bile duct stones after cholecystectomy

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Clinical features of patients with recurrent primary common bile duct stones after cholecystectomy

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