How far is the functional cure of chronic hepatitis B from complete cure?

Corresponding author: GAO Zhiliang， gaozhl@mail.sysu.edu.cn （ORCID： 0000-0001-7611-4416）
Received Date: 2024-10-17
Accepted Date: 2024-11-29
Published Date: 2025-01-25

Abstract

Abstract

Functional cure is currently the ideal treatment endpoint for chronic hepatitis B （CHB） in China and globally. HBsAg seroclearance and HBV DNA that cannot be detected in peripheral blood for more than 24 weeks marks the regression of hepatitis B virus （HBV） infection. However， there is still a lack of systematic description of the characteristics of intrahepatic HBV markers after HBsAg seroclearance. This article elaborates on the issues including the latest definition of functional cure， the characteristics of intrahepatic virological markers after HBsAg seroclearance， the significance of ultrasensitive serum HBsAg detection， and antiviral therapy for CHB patients with a low level of HBsAg， so as to improve the understanding of functional cure among clinicians.
- Hepatitis B， Chronic,
- Functional Cure,
- Hepatitis B Surface Antigens,
- DNA， Viral

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References(79)

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How far is the functional cure of chronic hepatitis B from complete cure?

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How far is the functional cure of chronic hepatitis B from complete cure?

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