钟伏弟,2013年毕业于中山大学获得理学博士学位,副研究员,硕士生导师,广西医科大学杏湖学者。担任广西肝胆疾病基础及临床应用研究重点实验室主任,广西肝脏疾病免疫与代谢研究重点实验室副主任。主要从事肝脏疾病与免疫代谢研究,围绕代谢相关脂肪性肝病、酒精性脂肪肝病等前沿问题,从免疫、代谢等方面开展相关研究,为肝脏疾病的诊治提供理论依据。主持国家自然科学基金3项,广西自然科学基金2项,作为骨干参与“111”计划、国家重点研发计划等项目。以第一作者或通讯作者先后在Cell Research,Nucleic Acids Research,American Journal of Transplantation,Journal of Gastroenterology等杂志发表学术论文,获得广西科学技术特别贡献奖特等奖(3/18)。
主要研究成果:
1)Zhong F, Hu Z, Jiang K, Lei B, Wu Z, Yuan G, Luo H, Dong C, Tang B, Zheng C, Yang S, Zeng Y, Guo Z, Yu S, Su H, Zhang G, Qiu X, Tomlinson S, He S. Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis. Cell Res. 2019 Jul;29(7):548-561. doi: 10.1038/s41422-019-0175-2.(中国科学院1区)
2)Jiang K, Lu S, Li D, Liu M, Jin H, Lei B, Wang S, Long K, He S, Zhong F*. Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization. J Gastroenterol. 2023 Sep;58(9):894-907. doi: 10.1007/s00535-023-02002-w.(中国科学院2区)
3)Lu S, Jin H, Nong T, Li D, Long K, Chen Y, Li Y, Xing H, Pan T, He S, Jiang K*, Zhong F*. Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization. Free Radic Biol Med. 2024 Sep 12;224:506-520. doi: 10.1016/j.freeradbiomed.2024.09.011.(中国科学院2区top)
4)Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S*, Zhong F*. FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway. Sci Rep. 2024 Sep 10;14(1):21135. doi: 10.1038/s41598-024-71311-8.(中国科学院2区)
5)Zhou Y, Yuan G, Zhong F*, He S*. Lin C, Lei B, Dong C, Chen J, Chen S, Jiang K, Zeng Y, Su H, Jin H, Qiu X, Li Z, Hu Z, Yu S, Zhang C, Lu S, Atkinson C, Tomlinson S, Zhong F*, Yuan G*, He S*. Complement inhibition alleviates donor brain death-induced liver injury and posttransplant cascade injury by regulating phosphoinositide 3-kinase signaling. Am J Transplant. 2023 Apr;23(4):484-497. doi: 10.1016/j.ajt.2023.01.019.(中国科学院2区top)
6)Zhou Y, Yuan G, Zhong F*, He S*. Roles of the complement system in alcohol-induced liver disease. Clin Mol Hepatol. 2020 Oct;26(4):677-685. doi: 10.3350/cmh.2020.0094.(中国科学院1区)