Omeprazole combined with sucralfate on the prevention of upper gastrointestinal rebleeding in the cirrhosis with hepatitis B

Objective To study the effect of continuous treatment with oral omeprazole combined with sucralfate in preventing upper gastrointestinal rebleeding in liver cirrhosis with hepatitis B.Methods Sixty two patients who had upper gastrointestinal hemorrhage were divided into prevention group and control group.Thirty two patients of prevention group took oral omeprazole combined with sucralfate for 12 months, while the patients in control group didn't take the medicine.The number of patients who had upper gastrointestinal hemorrhage and rebleeding, and the number of inpatients in the two groups were compared.Results The number of patients who had reoccurence of upper gastrointestinal hemorrhage and the number of inpatients in prevention group were lower than that of in control group after 12 months (P<0.001) .Conclusion Omeprazole combined with sucralfate is an effective method to prevent upper gastrointestinal rebleeding in liver cirrhosis with hepatitis B.