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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2010
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The effect of S-adenosyl-methionine treatment on drug-induced liver injury

  • Published Date: 2010-06-20
  • Objective To evaluate the therapeutic efficacy and safety of different dose S-adenosyl-L-methionine on drug-induced cholestasis liver injury and mixed liver injury.Methods a total of 66 patients suffered from drug-induced cholestasis liver injury and mixed liver injury were randomly divided into treatment group and control group.Furthermore, the treatment group was divided into 2 groups as treatment 1 group and treatment 2 group.The control group was treated with common therapy, while the treatment 1 group was treated with S-adenosyl-L-methionin up to 1 g/d as well as the treatment 2 group was treated with S-adenosyl-methionin up to 2 g/d.After 4 weeks of treatment, liver function was measured.Results The level of total bilirubin and alanine transaminase significantly decreased in the treatment group than the control group (P < 0.05) .Moreover, no adverse reactions were observed.Total bilirubin and alanine transarninase significantly decreased in treatment 2 group compared to treatment 1 group (P < 0.01) .Conclusion The therapeutic efficacy and safety of large dose S-adenosyl-L-methionin in treating drug-induced cholestasis liver injury and mixed liver injury is better compared to the common therapy.

     

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