Objective To investigate the clinical characteristics and treatment of liver failure patients with spontaneous bacterial peritonitis (SBP) .Methods A total of 201 liver cirrhosis patients with SBP were retrospectively divided into liver failure group and control group.The complete blood count, ascites cell count and ascites culture were compared between the two groups.The curative effect of antibiotic therapy on liver failure patients with SBP was observed.Results The ratio of neutrophil, ratio of PCT < 2, and ascites cell count in liver failure group were higher than the non liver failure group (P < 0.05) .The positivity rates of ascites culture in both groups were lower.The positivity rate of Escherichia coli and the sensitivity to Moxifloxacin in liver failure group was lower than the control group (35.0% vs 72.2%, 25.0% vs 66.7%, P > 0.05) .The clinical effect of treatment with Imipenem trial and Moxifloxacin group were significantly higher than the Cephalosporin group (P < 0.05) .The treatment duration with Imipenem or Moxifloxacin was significantly shorter than that of Cephalosporin (P < 0.05) .Conclusion The disease severity is higher but the ascites culture positivity rate is lower in liver failure patients compared to the control group.The sensitivity to Moxifloxacin in liver failure group was lower.The curative effect of Imipenem and Moxifloxacin is better than Cephalosporins.
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