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CN 22-1108/R
Volume 42 Issue 6
Jun.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(6): 1426-1432

Role of ferroptosis in the progression and treatment of liver fibrosis

DOI: 10.12449/JCH260628

  • Department of Laboratory Medicine，The Second Xiangya Hospital of Central South University；Hunan Provincial Center for Clinical Molecular Diagnostics；Hunan Engineering Research Center for Molecular Diagnostic Technology；Hunan Clinical Research Center for Molecular Diagnosis of Infectious Diseases，Changsha 410011，China

Research funding:

National Natural Science Foundation of China (82270658);

Central South University Graduate Innovation Project (2024XQLH103)

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  • Corresponding author: HU Min， huminjyk@csu.edu.cn （ORCID： 0000-0001-7886-8174）
  • Received Date: 2025-08-13
  • Accepted Date: 2025-09-30
  • Published Date: 2026-06-25
    Abstract
  • Liver fibrosis is a critical pathological process in the progression of chronic liver diseases and is mainly driven by the activation of hepatic stellate cells， and it is characterized by excessive deposition of extracellular matrix. Programmed cell death is widely observed in liver fibrosis and plays diverse roles in different types of cells. It is not only a mechanism for maintaining cellular homeostasis through metabolism， but it can also regulate the development and progression of diseases. Ferroptosis has recently emerged as a research focus due to its close association with lipid metabolism. This article systematically reviews the related concepts of lipid metabolism， ferroptosis， and liver fibrosis， analyzes the bridging role and dual regulatory function of ferroptosis in lipid metabolism and liver fibrosis， and further highlights the clinical application value of targeting ferroptosis in hepatic stellate cells for the treatment of liver fibrosis， in order to provide new perspectives for the mechanistic studies on liver fibrosis and the optimization of related clinical intervention strategies.

     

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