Association between endoplasmic reticulum stress and ferroptosis in metabolic associated fatty liver disease

Liang SHI; Zhanjie CHANG; Chunxiao YAN; Junzhe JIAO; Ruijuan YAN; Shuguang YAN; Jingtao LI; Haibo ZHANG

doi:10.12449/JCH260624

Volume 42 Issue 6

Jun. 2026

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Article Navigation > Journal of Clinical Hepatology > 2026 > 42(6): 1398-1403

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Association between endoplasmic reticulum stress and ferroptosis in metabolic associated fatty liver disease

DOI: 10.12449/JCH260624

1.
School of Traditional Chinese Medicine，Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712046，China
2.
First Ward Area of Hepatology Hospital，The Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712000，China
3.
School of Basic Medical Sciences，Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712046，China

Research funding:

National Natural Science Foundation of China (82174330);

National Natural Science Foundation of China (82405335);

Youth Innovation Team of Shaanxi Provincial Department of Education (25JP049);

"Double Chain Integration"Innovation Team of Shaanxi Provincial Administration of Traditional Chinese Medicine (2022-SLRH-LJ-002);

Major Science and Technology Innovation Special Project of Xianyang City (L2023-ZDKJ-CYJQ-SF-011);

University-level High-level Key Discipline of Traditional Chinese Medicine,Shaanxi University of Chinese Medicine (2024XKZD19);

Innovative Talents for Traditional Chinese Medicine Research of Shaanxi Province (2025-CXRC-19);

Program for the Construction of Scientific and Technological Innovation Talent System,Shaanxi University of Chinese Medicine (2024-KJXX-03)

More Information

Corresponding author: ZHANG Haibo， 15289317954@163.com （ORCID： 0000-0003-1755-1813）
Received Date: 2025-09-02
Accepted Date: 2025-12-31
Published Date: 2026-06-25

Abstract

Abstract

Metabolic associated fatty liver disease （MAFLD） is a highly prevalent chronic liver disease worldwide， and the mechanism underlying its progression to metabolic associated steatohepatitis and liver fibrosis remain unclear. Endoplasmic reticulum stress （ERS） and ferroptosis （Fer） are deeply involved in the pathological evolution of MAFLD. This article systematically reviews the core regulatory mechanisms of ERS and its role in regulating lipid metabolism， inflammation response， and cell apoptosis in MAFLD. It also analyzes the core mechanism of Fer and discusses the predisposing factors for Fer in the pathological microenvironment of MAFLD， as well as the role of Fer in exacerbating hepatocyte death and activating the progression of liver fibrosis. This article proposes that the crosstalk between ERS and Fer is a key driver for the progression of MAFLD， which provides new references and ideas for the clinical intervention of MAFLD.
- Metabolic Dysfunction-Associated Fatty Liver Disease,
- Endoplasmic Reticulum Stress,
- Ferroptosis

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References(40)

References

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Association between endoplasmic reticulum stress and ferroptosis in metabolic associated fatty liver disease

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Association between endoplasmic reticulum stress and ferroptosis in metabolic associated fatty liver disease

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