Hepatic encephalopathy （HE） is a major complication of liver cirrhosis associated with a poor prognosis， imposing a heavy burden on patients， families， and the healthcare system. In recent years， although significant advances have been made in the diagnosis and management strategies for HE， many issues remain to be resolved. In 2026， the American College of Gastroenterology released a clinical guideline on HE， covering recommendations on the diagnosis， management， and prevention of HE， which provides guidance for clinical practice. This article gives an excerpt of the recommendations and key views from this guideline.
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