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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 42 Issue 6
Jun.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(6): 1260-1265

Current research status and challenges of pancreatic portal hypertension

DOI: 10.12449/JCH260604

  • Department of Gastroenterology，Peking University First Hospital，Beijing 100034，China

Research funding:

National Science and Technology Major Project (2025ZD01906300);

National Science and Technology Major Project (2025ZD01906303)

More Information
  • Corresponding author: DAI Yun， daiyun@bjmu.edu.cn （ORCID： 0000-0002-8854-631X）
  • Received Date: 2026-01-12
  • Accepted Date: 2026-04-14
  • Published Date: 2026-06-25
    Abstract
  • Pancreatic portal hypertension （PPH） is a type of regional portal hypertension secondary to pancreatic diseases and their complications. Unlike portal hypertension caused by liver cirrhosis， PPH is confined to the splenic venous system， and most patients tend to have normal liver function. Splenic vein obstruction and impaired blood return are the core mechanisms underlying the development of PPH， and isolated gastric fundal varices represent a characteristic manifestation of PPH. For patients with pancreatic diseases， it is necessary to establish early warning and risk stratification strategies， and high-quality studies are needed to further confirm the safety and efficacy of anticoagulation， surgical approaches， and interventional therapies in patients with PPH. This article systematically reviews the pathogenesis， etiological classification， clinical features， and key diagnostic points of PPH and discusses the current status of PPH treatment and existing challenges.

     

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