Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets

Yujie ZHAI; Xiangxiang LI; Chujiang WU; Yanan ZHANG; Yuxin HE; Zhongyu LIU; Jiucong ZHANG; Bin LIANG

doi:10.12449/JCH251033

Volume 41 Issue 10

Oct. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(10): 2180-2186

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Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets

DOI: 10.12449/JCH251033

Yujie ZHAI^{1, 2},
Xiangxiang LI²,
Chujiang WU²,
Yanan ZHANG²,
Yuxin HE²,
Zhongyu LIU²,
Jiucong ZHANG^{2
,
,
,},
Bin LIANG^{3
,
,
,}

1.
The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China
2.
Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
3.
Department of Gastroenterology，The Fifth People’s Hospital of Ganzhou，Ganzhou，Jiangxi 341000，China

Research funding:

Gansu Provincial Health Commission Subjects (GSWSKY2023-34);

Lanzhou Science and Technology Program (2023-2-29);

Lanzhou Youth Science and Technology Talent Innovation Program (2024-QN-39)

More Information

Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）; LIANG Bin， 123450632@qq.com （ORCID： 0000-0003-4427-8445）
Received Date: 2025-03-25
Accepted Date: 2025-04-17
Published Date: 2025-10-25

Abstract

Abstract

Liver diseases are a group of complex clinical conditions caused by various factors and can lead to hepatocyte damage and liver dysfunction， posing a serious threat to human health. The cyclic GMP-AMP synthase （cGAS）-stimulator of interferon genes （STING） signaling pathway plays a key regulatory role in the course of liver diseases and is involved in the development， progression， and treatment of various diseases such as viral hepatitis， nonalcoholic fatty liver disease， liver fibrosis， and liver cancer. This article reviews the regulatory mechanisms of the cGAS-STING signaling pathway in processes such as inflammation， autophagy， antiviral response， and oxidative stress， analyzes its molecular function in liver diseases， and explores its application prospect as a potential target for the treatment of liver diseases， in order to provide a theoretical basis for developing novel therapeutic strategies for liver diseases.
- Liver Diseases,
- cGAS-STING Signaling Pathway,
- Pathologic Processes,
- Therapeutics

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References(52)

References

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Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets

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Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets

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