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Volume 41 Issue 10
Oct.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(10): 2161-2167

Mechanism traditional Chinese medicine extract preventing and treating hepatocellular carcinoma by targeting the adenosine monophosphate-activated protein kinase signaling pathway

DOI: 10.12449/JCH251030
  • 1.

    The Second Clinical Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China

  • 2.

    Department of Hepatology and Spleen-Stomach，Henan Provincial Hospital of Traditional Chinese Medicine （The Second Affiliated Hospital of Henan University of Chinese Medicine），Zhengzhou 450002，China

Research funding:

Joint Research Project of China Center for the Development of Traditional Chinese Medicine Science and Technology of the State Administration of Traditional Chinese Medicine (CXZH202304);

National Natural Science Foundation of China (82305074);

Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talent Project （Zhongjing Project） Traditional Chinese Medicine Discipline Leading Talent Project (Yuwei Zhongyi Han ［2021］ No.08)

More Information
  • Corresponding author: ZHANG Qinsheng， hnszqs@163.com （ORCID： 0000-0001-5960-0543）
  • Received Date: 2025-02-16
  • Accepted Date: 2025-04-11
  • Published Date: 2025-10-25
    Abstract
  • Hepatocellular carcinoma （HCC） is one of the most common malignant tumors with high incidence and mortality rates worldwide， which brings a huge burden to the physical and mental health and socio-economic life of patients. The adenosine monophosphate-activated protein kinase （AMPK） signaling pathway serves as the regulatory center of cellular energy metabolism and is closely associated with the biological activities of HCC cells， including autophagy， apoptosis， and angiogenesis， and it has become a hot topic in current cancer research. Traditional Chinese medicine drugs are abundant in natural components such as flavonoids， alkaloids， and phenols and have the characteristics of multiple targets， pathways， components， and hierarchies. By targeting the AMPK signaling pathway， these components can be used alone or in combination with conventional antitumor therapies to exert an anti-tumor effect on HCC from various aspects. This article reviews and summarizes the extracts of traditional Chinese medicine that target the AMPK signaling pathway for the prevention and treatment of HCC， in order to provide a theoretical basis and a reference for the clinical application of traditional Chinese medicine in the treatment of HCC and the development of related drugs.

     

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