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Volume 41 Issue 10
Oct.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(10): 2149-2153

Application of novel oral anticoagulants in patients with liver cirrhosis

DOI: 10.12449/JCH251028
  • 1.

    The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China

  • 2.

    Department of Infectious Diseases，Lanzhou First People’s Hospital，Lanzhou 730050，China

Research funding:

Scientific Research Project in the Health Industry of Lanzhou City (A2024001);

Scientific Research Project in the Health Industry of Lanzhou City (A2024010);

Science and Technology Planning Project in Gansu Province (25JRRA790)

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  • Corresponding author: ZHOU Ning， zhouning198278@163.com （ORCID： 0000-0001-8988-2860）
  • Received Date: 2025-03-26
  • Accepted Date: 2025-04-30
  • Published Date: 2025-10-25
    Abstract
  • Liver cirrhosis is a common chronic progressive liver disease， and such patients often have coagulation disorders， which may lead to thrombotic and hemorrhagic events. While traditional anticoagulant therapies have various limitations， the emergence of novel oral anticoagulants （NOAC） provides new options for anticoagulation treatment in patients with liver cirrhosis. This article comprehensively reviews the application of NOAC in patients with liver cirrhosis， discusses their advantages and potential risks， analyzes their pharmacokinetic and pharmacodynamic characteristics， and evaluates their efficacy and safety in the prevention and treatment of cirrhosis-associated thrombosis based on clinical evidence， in order to provide a reference for clinical decision-making.

     

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