Regulatory role of macrophage glycolysis in metabolic dysfunction-associated fatty liver disease

Jiahan CHANG; Yujie CAI; Yixin HOU; Juqiang HAN

doi:10.12449/JCH251025

Volume 41 Issue 10

Oct. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(10): 2130-2135

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Regulatory role of macrophage glycolysis in metabolic dysfunction-associated fatty liver disease

DOI: 10.12449/JCH251025

Jiahan CHANG¹,
Yujie CAI¹,
Yixin HOU^{2
,
,
,},
Juqiang HAN^{1
,
,
,}

1.
Department of Ambulatory Medicine，The Seventh Medical Center，General Hospital of PLA，Beijing 100700，China
2.
Center of Integrative Medicine，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China

Research funding:

National Natural Science Foundation of China (81970512)

More Information

Corresponding author: HOU Yixin， xuexin162@163.com （ORCID： 0000-0001-8233-7210）; HAN Juqiang， hanjuqiang2014@126.com （ORCID： 0000-0003-2328-0300）
Received Date: 2025-03-13
Accepted Date: 2025-05-16
Published Date: 2025-10-25

Abstract

Abstract

Metabolic dysfunction-associated fatty liver disease （MAFLD） is a common chronic liver disease in clinical practice， and macrophages are directly involved in the development， progression， and prognosis of MAFLD. Studies have confirmed that glucose metabolic reprogramming in macrophages directly affects immune function， which in turn affects the local inflammatory environment of liver and hepatocyte metabolism. This article reviews the changes in glucose metabolism of macrophages and the corresponding key molecules in the pathogenesis of MAFLD， in order to provide new targets and strategies for the prevention and treatment of MAFLD in the future.
- Metabolic Dysfunction-Associated Fatty Liver Disease,
- Macrophages,
- Glycolysis,
- Metabolic Reprogramming

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References(45)

References

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Regulatory role of macrophage glycolysis in metabolic dysfunction-associated fatty liver disease

DOI: 10.12449/JCH251025

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Regulatory role of macrophage glycolysis in metabolic dysfunction-associated fatty liver disease

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