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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 10
Oct.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(10): 2125-2129

Efficacy of interferon in treatment of chronic hepatitis B and the synergistic mechanism of traditional Chinese medicine in toxicity reduction and efficacy enhancement： A study based on the theory of latent pathogens

DOI: 10.12449/JCH251024
  • 1.

    Graduate School of Hunan University of Chinese Medicine，Changsha 410208，China

  • 2.

    Department of Hepatology，The First Hospital of Hunan University of Chinese Medicine，Changsha 410007，China

Research funding:

National Natural Science Foundation of China (8197152432);

Double First-Class Discipline Construction Project of Hunan University of Chinese Medicine in 2023 (6001001007)

More Information
  • Corresponding author: SUN Kewei， keweisun550@163.com （ORCID： 0009-0003-6411-6707）
  • Received Date: 2025-03-12
  • Accepted Date: 2025-04-14
  • Published Date: 2025-10-25
    Abstract
  • In the traditional theoretical system of traditional Chinese medicine， latent pathogenic factors deeply hiding in the liver and gallbladder of the Jueyin meridian are the core pathogenesis of chronic hepatitis B. Interferon can regulate immunity and eliminate viruses， and clinical cure can be achieved by penetrating and removing pathogenic factors and toxins. However， it often causes dizziness and confusion reactions in the initial stage of treatment， and long-term use can damage Qi-blood； furthermore， its therapeutic effect depends on the patient’s own vital Qi. When traditional Chinese medicine is used in combination with interferon， drug compatibility should be adjusted according to the dynamic changes of pathogenesis， which can reduce adverse reactions， enhance the therapeutic outcome， expand the applicable population of interferon， and improve the clinical symptoms of patients.

     

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