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Volume 41 Issue 5
May  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(5): 975-982

The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets

DOI: 10.12449/JCH250526

  • Laboratory of Gastrointestinal Cancer and Liver Disease，West China Hospital，Sichuan University，Chengdu 610000，China

Research funding:

National Natural Science Foundation of China (82100552);

Sichuan University-Dazhou Cooperation Fundation (2022CDDZ-18)

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  • Corresponding author: FAN Xiaoli， fanxiaoli@scu.edu.cn （ORCID： 0000-0002-8434-2969）
  • Received Date: 2024-09-18
  • Accepted Date: 2024-10-22
  • Published Date: 2025-05-25
    Abstract
  • Tissue-resident memory T cells （TRM cells） are a subset of memory T cells that reside in tissues， exhibit tissue specificity， and do not recirculate. When potential hazards threaten the liver， such as pathogen invasion （bacteria， viruses， etc.） and excessive autoimmune responses， TRM cells are essential as the first line of immune defense， playing an important role in viral hepatitis， autoimmune liver disease， metabolic dysfunction-associated fatty liver disease， liver cirrhosis， and liver transplantation. Here， we present the immunophenotypes of TRM cells in the liver and their surface markers and transcriptional profiles， aiming to clarify the role of TRM cells in chronic liver diseases and explore their potential function as therapeutic targets in immunotherapy.

     

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