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CN 22-1108/R
Volume 41 Issue 5
May  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(5): 914-920

Expression and prognostic value of triggering receptor expressed on myeloid cells-1 in patients with cirrhotic ascites and intra-abdominal infection

DOI: 10.12449/JCH250517
  • 1a.

    Department of Infection，The Fifth Hospital of Shijiazhuang，Shijiazhuang 050021，China

  • 1b.

    Institute of Clinical Medicine，The Fifth Hospital of Shijiazhuang，Shijiazhuang 050021，China

  • 2.

    Epidemiology Teaching and Research Office，School of Public Health，Hebei Medical University，Shijiazhuang 050017，China

Research funding:

Shijiazhuang Science and Technology Support Plan Project (181460753)

More Information
  • Corresponding author: YUAN Wenfang， 413699442@qq.com （ORCID： 0009-0009-4296-715X）
  • Received Date: 2024-08-05
  • Accepted Date: 2025-01-23
  • Published Date: 2025-05-25
    Abstract
  •   Objective  To analyze the expression level of triggering receptor expressed on myeloid cells-1 （TREM-1） in serum and ascites of patients with cirrhotic ascites， and to investigate its correlation with clinical features and inflammatory markers and its role in the diagnosis of infection and prognostic evaluation.  Methods  A total of 110 patients with cirrhotic ascites who were hospitalized in The Fifth Hospital of Shijiazhuang from January 2019 to December 2020 were enrolled， and according to the presence or absence of intra-abdominal infection， they were divided into infection group with 72 patients and non-infection group with 38 patients. The patients with infection were further divided into improvement group with 38 patients and non-improvement group with 34 patients. Clinical data and laboratory markers were collected from all patients. Serum and ascites samples were collected， and ELISA was used to measure the level of TREM-1. The independent-samples t test was used for comparison of normally distributed continuous data between two groups； the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups， and the Kruskal-Wallis H test was used for comparison between multiple groups； the chi-square test was used for comparison of categorical data between two groups. A Spearman correlation analysis was used to investigate the correlation between indicators. A multivariate Logistic regression analysis was used to identify the influencing factors for the prognosis of patients with cirrhotic ascites and infection. The receiver operating characteristic （ROC） curve was used to evaluate the diagnostic and prognostic efficacy of each indicator， and the Delong test was used for comparison of the area under the ROC curve （AUC）.  Results  The level of TREM-1 in ascites was significantly positively correlated with that in serum （r=0.50， P<0.001）. Compared with the improvement group， the non-improvement group had a significantly higher level of TREM-1 in ascites （Z=-2.391， P=0.017） and serum （Z=-2.544， P=0.011）， and compared with the non-infection group， the infection group had a significantly higher level of TREM-1 in ascites （Z=-3.420， P<0.001）， while there was no significant difference in the level of TREM-1 in serum between the two groups （P>0.05）. The level of TREM-1 in serum and ascites were significantly positively correlated with C-reactive protein （CRP）， procalcitonin （PCT）， white blood cell count， and neutrophil-lymphocyte ratio （r=0.288， 0.344， 0.530， 0.510， 0.534， 0.454， 0.330， and 0.404， all P<0.05）. The ROC curve analysis showed that when PCT， CRP， and serum or ascitic TREM-1 were used in combination for the diagnosis of cirrhotic ascites with infection， the AUCs were 0.715 and 0.740， respectively. The multivariate Logistic regression analysis showed that CRP （odds ratio ［OR］=1.019， 95% confidence interval ［CI］： 1.001‍ ‍—‍ ‍1.038， P=0.043） and serum TREM-1 （OR=1.002， 95%CI： 1.000‍ ‍—‍ ‍1.003， P=0.016） were independent risk factors for the prognosis of patients with cirrhotic ascites and infection， and the combination of these two indicators had an AUC of 0.728 in predicting poor prognosis.  Conclusion  The level of TREM-1 is closely associated with the severity of infection and prognosis in patients with cirrhotic ascites， and combined measurement of TREM-1 and CRP/PCT can improve the diagnostic accuracy of infection and provide support for prognostic evaluation.

     

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    • References(20)
  • [1]
    WANG YK, WANG MQ, LIU CR, et al. Global burden of liver cirrhosis 1990-2019 and 20 years forecast: Results from the global burden of disease study 2019[J]. Ann Med, 2024, 56( 1): 2328521. DOI: 10.1080/07853890.2024.2328521.
    [2]
    ZHANG XY, ZHAO JJ, LIANG Y, et al. Research progress on relationship between TREMs and ulcerative colitis and related carcinogenesis[J]. Chin J Immunol, 2023, 39( 1): 211- 214. DOI: 10.3969/j.issn.1000-484X.2023.01.035.

    张馨月, 赵俊佳, 梁媛, 等. 髓样细胞触发受体与溃疡性结肠炎及其相关癌变的研究进展[J]. 中国免疫学杂志, 2023, 39( 1): 211- 214. DOI: 10.3969/j.issn.1000-484X.2023.01.035.
    [3]
    RAO SZ, HUANG JS, SHEN ZJ, et al. Inhibition of TREM-1 attenuates inflammation and lipid accumulation in diet-induced nonalcoholic fatty liver disease[J]. J Cell Biochem, 2019, 120( 7): 11867- 11877. DOI: 10.1002/jcb.28468.
    [4]
    WU XJ, CAI B, LU W, et al. HBV upregulated triggering receptor expressed on myeloid cells-1(TREM-1) expression on monocytes participated in disease progression through NF-κB pathway[J]. Clin Immunol, 2021, 223: 108650. DOI: 10.1016/j.clim.2020.108650.
    [5]
    Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the management of ascites and complications in cirrhosis[J]. J Clin Hepatol, 2017, 33( 10): 1847- 1863. DOI: 10.3969/j.issn.1001-5256.2017.10.003.

    中华医学会肝病学分会. 肝硬化腹水及相关并发症的诊疗指南[J]. 临床肝胆病杂志, 2017, 33( 10): 1847- 1863. DOI: 10.3969/j.issn.1001-5256.2017.10.003.
    [6]
    LI BL, CHEN JJ. Diagnosis and treatment of abdominal infection in patients with liver cirrhosis: Advances and challenges[J]. J Clin Hepatol, 2021, 37( 4): 757- 760. DOI: 10.3969/j.issn.1001-5256.2021.04.003.

    黎倍伶, 陈金军. 肝硬化腹腔感染的诊疗进展及挑战[J]. 临床肝胆病杂志, 2021, 37( 4): 757- 760. DOI: 10.3969/j.issn.1001-5256.2021.04.003.
    [7]
    ZHANG LL, HU JH, DAI XC, et al. Research progress on the relationship between cirrhotic ascites and intestinal mucosal barrier function[J/CD]. Chin J Liver Dis(Electronic Version), 2023, 15( 2): 23- 27. DOI: 10.3969/j.issn.1674-7380.2023.02.005.

    张丽丽, 胡建华, 代欣璨, 等. 肝硬化腹水与肠黏膜屏障功能关系研究进展[J/CD]. 中国肝脏病杂志(电子版), 2023, 15( 2): 23- 27. DOI: 10.3969/j.issn.1674-7380.2023.02.005.
    [8]
    SISKIND S, BRENNER M, WANG P. TREM-1 modulation strategies for sepsis[J]. Front Immunol, 2022, 13: 907387. DOI: 10.3389/fimmu.2022.907387.
    [9]
    JOLLY L, CARRASCO K, SALCEDO-MAGGUILLI M, et al. sTREM-1 is a specific biomarker of TREM-1 pathway activation[J]. Cell Mol Immunol, 2021, 18( 8): 2054- 2056. DOI: 10.1038/s41423-021-00733-5.
    [10]
    da SILVA-NETO PV, de CARVALHO JCS, PIMENTEL VE, et al. sTREM-1 predicts disease severity and mortality in COVID-19 patients: Involvement of peripheral blood leukocytes and MMP-8 activity[J]. Viruses, 2021, 13( 12): 2521. DOI: 10.3390/v13122521.
    [11]
    VANDESTIENNE M, BRAIK R, LAVILLEGRAND JR, et al. Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study[J]. Front Cardiovasc Med, 2023, 10: 1098914. DOI: 10.3389/fcvm.2023.1098914.
    [12]
    TREBICKA J, HERNAEZ R, SHAWCROSS DL, et al. Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure(ACLF) and the role of biomarkers[J]. Gut, 2024, 73( 6): 1015- 1024. DOI: 10.1136/gutjnl-2023-330584.
    [13]
    CHANG W, PENG F, MENG SS, et al. Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1(sTREM-1) in suspected sepsis: A meta-analysis[J]. BMC Immunol, 2020, 21( 1): 2. DOI: 10.1186/s12865-020-0332-x.
    [14]
    QIN Q, LIANG LJ, XIA YQ. Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis[J]. Infect Genet Evol, 2021, 96: 105074. DOI: 10.1016/j.meegid.2021.105074.
    [15]
    XIA Y, WANG Y, HE HW, et al. Predictive value of white blood cell, procalcitonin and high-sensitivity C-reactive protein for the bloodstream infection in the super-elderly critically-ill patients[J]. Natl Med J China, 2019, 99( 5): 365- 369. DOI: 10.3760/cma.j.issn.0376-2491.2019.05.009.

    夏莹, 王颖, 何怀武, 等. 白细胞、降钙素原和超敏C反应蛋白在超高龄重症患者血流感染的诊断预测价值[J]. 中华医学杂志, 2019, 99( 5): 365- 369. DOI: 10.3760/cma.j.issn.0376-2491.2019.05.009.
    [16]
    YANG P, XIAO LY, YANG N, et al. The evaluation value of procalcitonin and prothrombin activity in the prognosis of liver failure complicated by infection[J]. Chin J Nosocomiol, 2022, 32( 4): 531- 534. DOI: 10.11816/cn.ni.2022-210509.

    杨平, 肖乐尧, 杨娜, 等. 降钙素原和凝血酶原活动度在肝衰竭合并感染预后中的评估价值[J]. 中华医院感染学杂志, 2022, 32( 4): 531- 534. DOI: 10.11816/cn.ni.2022-210509.
    [17]
    KANG MK, LEE YR, PARK SY, et al. Diagnostic performance of procalcitonin for bacterial infection in severe alcoholic hepatitis compared with C-reactive protein[J]. BMC Gastroenterol, 2024, 24( 1): 428. DOI: 10.1186/s12876-024-03519-x.
    [18]
    SUN HF, FENG JG, TANG LL. Function of TREM1 and TREM2 in liver-related diseases[J]. Cells, 2020, 9( 12): 2626. DOI: 10.3390/cells9122626.
    [19]
    COLONNA M. The biology of TREM receptors[J]. Nat Rev Immunol, 2023, 23( 9): 580- 594. DOI: 10.1038/s41577-023-00837-1.
    [20]
    LIN XY, LI C, ZHANG T, et al. Changes of intestinal wall barrier function and its correlation with susceptibility to infection in patients with cirrhotic portal hypertension[J]. Chin J Hepatol, 2023, 31( 1): 70- 76. DOI: 10.3760/cma.j.cn501113-20220118-00031.

    林晓宇, 李琛, 张婷, 等. 肝硬化门静脉高压症患者肠壁屏障功能的改变及其与易发感染的关系[J]. 中华肝脏病杂志, 2023, 31( 1): 70- 76. DOI: 10.3760/cma.j.cn501113-20220118-00031.
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