| [1] |
BR VK, SARIN SK. Acute-on-chronic liver failure: Terminology, mechanisms and management[J]. Clin Mol Hepatol, 2023, 29( 3): 670- 689. DOI: 10.3350/cmh.2022.0103.
|
| [2] |
AGGARWAL A, BISWAS S, ARORA U, et al. Definitions, etiologies, and outcomes of acute on chronic liver failure: A systematic review and meta-analysis[J]. Clin Gastroenterol Hepatol, 2024, 22( 11): 2199- 2210. e 25. DOI: 10.1016/j.cgh.2024.04.018.
|
| [3] |
Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure[J]. Chin J Clin Infect Dis, 2008, 1( 1): 47- 53. DOI: 10.3760/cma.j.issn.1674-2397.2008.01.014.
中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病人工肝学组. 肝衰竭诊疗指南[J]. 中华临床感染病杂志, 2008, 1( 1): 47- 53. DOI: 10.3760/cma.j.issn.1674-2397.2008.01.014.
|
| [4] |
Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2012)[J]. Chin J Clin Infect Dis, 2012, 5( 6): 321- 327. DOI: 10.3760/cma.j.issn.1674-2397.2012.06.001.
中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2012年版)[J]. 中华临床感染病杂志, 2012, 5( 6): 321- 327. DOI: 10.3760/cma.j.issn.1674-2397.2012.06.001.
|
| [5] |
Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. J Clin Hepatol, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 临床肝胆病杂志, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
|
| [6] |
Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2024 version)[J]. J Clin Hepatol, 2024, 40( 12): 2371- 2387. DOI: 10.12449/JCH241206.
中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2024年版)[J]. 临床肝胆病杂志, 2024, 40( 12): 2371- 2387. DOI: 10.12449/JCH241206.
|
| [7] |
Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Nutrition and Regeneration in End-Stage Liver Disease Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. Chin J Hepatol, 2025, 33( 4): 329- 339. DOI: 10.3760/cma.j.cn501113-20250312-00089.
中华医学会肝病学分会重型肝病与人工肝学组, 中华医学会肝病学分会终末期肝病营养与再生学组. 慢加急性肝衰竭诊治指南(2025年版)[J]. 中华肝脏病杂志, 2025, 33( 4): 329- 339. DOI: 10.3760/cma.j.cn501113-20250312-00089.
|
| [8] |
OHNISHI H, SUGIHARA J, MORIWAKI H, et al. Acute-on-chronic liver failure[J]. Ryoikibetsu Shokogun Shirizu, 1995( 7): 217- 219.
|
| [9] |
SARIN SK, CHOUDHURY A, SHARMA MK, et al. Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific association for the study of the liver(APASL): An update[J]. Hepatol Int, 2019, 13( 4): 353- 390. DOI: 10.1007/s12072-019-09946-3.
|
| [10] |
European Association for the Study of the Liver. EASL Clinical Practice Guidelines on acute-on-chronic liver failure[J]. J Hepatol, 2023, 79( 2): 461- 491. DOI: 10.1016/j.jhep.2023.04.021.
|
| [11] |
BAJAJ JS, O’LEARY JG, REDDY KR, et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures[J]. Hepatology, 2014, 60( 1): 250- 256. DOI: 10.1002/hep.27077.
|
| [12] |
BAJAJ JS, O’LEARY JG, LAI JC, et al. Acute-on-chronic liver failure clinical guidelines[J]. Am J Gastroenterol, 2022, 117( 2): 225- 252. DOI: 10.14309/ajg.0000000000001595.
|
| [13] |
KARVELLAS CJ, BAJAJ JS, KAMATH PS, et al. AASLD Practice Guidance on acute-on-chronic liver failure and the management of critically ill patients with cirrhosis[J]. Hepatology, 2024, 79( 6): 1463- 1502. DOI: 10.1097/HEP.0000000000000671.
|
| [14] |
CHOUDHURY A, KULKARNI AV, ARORA V, et al. Acute-on-chronic liver failure(ACLF): The‘Kyoto consensus’-steps from Asia[J]. Hepatol Int, 2025, 19( 1): 1- 69. DOI: 10.1007/s12072-024-10773-4.
|
| [15] |
CLÀRIA J, ARROYO V, MOREAU R. Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure[J]. JHEP Rep, 2023, 5( 9): 100807. DOI: 10.1016/j.jhepr.2023.100807.
|
| [16] |
ENGELMANN C, CLÀRIA J, SZABO G, et al. Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction[J]. J Hepatol, 2021, 75( Suppl 1): S49- S66. DOI: 10.1016/j.jhep.2021.01.002.
|
| [17] |
SARIN SK, KEDARISETTY CK, ABBAS Z, et al. Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver(APASL) 2014[J]. Hepatol Int, 2014, 8( 4): 453- 471. DOI: 10.1007/s12072-014-9580-2.
|
| [18] |
XU MM, LI SS, YANG YR, et al. Epidemiological characteristics of inpatients with liver failure at the Beijing You’an Hospital from 2012 to 2021[J]. Chin J Hepatol, 2024, 32( 1): 49- 57. DOI: 10.3760/cma.j.cn501113-20220824-00433.
徐曼曼, 李珊珊, 杨颜榕, 等. 2012至2021年北京佑安医院肝衰竭住院患者流行病学特征[J]. 中华肝脏病杂志, 2024, 32( 1): 49- 57. DOI: 10.3760/cma.j.cn501113-20220824-00433.
|
| [19] |
XU MM, CHEN Y. New perspectives in the definition and classification of acute-on-chronic liver failure[J]. Chin Med J(Engl), 2024, 137( 21): 2521- 2525. DOI: 10.1097/CM9.0000000000003289.
|
| [20] |
XU MM, KONG M, YU PF, et al. Clinical course and outcome patterns of acute-on-chronic liver failure: A multicenter retrospective cohort study[J]. J Clin Transl Hepatol, 2021, 9( 5): 626- 634. DOI: 10.14218/JCTH.2020.00179.
|
| [21] |
SCHWARZ M, SIMBRUNNER B, JACHS M, et al. High histamine levels are associated with acute-on-chronic liver failure and liver-related death in patients with advanced chronic liver disease[J]. Liver Int, 2024, 44( 11): 2904- 2914. DOI: 10.1111/liv.16056.
|
| [22] |
MO RD, ZHANG ZL, ZHOU YM, et al. A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis[J]. Lipids Health Dis, 2025, 24( 1): 35. DOI: 10.1186/s12944-025-02434-8.
|
| [23] |
ZHANG Y, TAN WT, WANG XB, et al. Metabolic biomarkers significantly enhance the prediction of HBV-related ACLF occurrence and outcomes[J]. J Hepatol, 2023, 79( 5): 1159- 1171. DOI: 10.1016/j.jhep.2023.07.011.
|
| [24] |
HU CH, JIANG N, ZHENG J, et al. Liver volume based prediction model for patients with hepatitis B virus-related acute-on-chronic liver failure[J]. J Hepatobiliary Pancreat Sci, 2022, 29( 12): 1253- 1263. DOI: 10.1002/jhbp.1112.
|
| [25] |
KAMATH PS, WIESNER RH, MALINCHOC M, et al. A model to predict survival in patients with end-stage liver disease[J]. Hepatology, 2001, 33( 2): 464- 470. DOI: 10.1053/jhep.2001.22172.
|
| [26] |
KIM WR, BIGGINS SW, KREMERS WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list[J]. N Engl J Med, 2008, 359( 10): 1018- 1026. DOI: 10.1056/NEJMoa0801209.
|
| [27] |
JALAN R, SALIBA F, PAVESI M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure[J]. J Hepatol, 2014, 61( 5): 1038- 1047. DOI: 10.1016/j.jhep.2014.06.012.
|
| [28] |
LI JQ, LIANG X, YOU SL, et al. Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure[J]. J Hepatol, 2021, 75( 5): 1104- 1115. DOI: 10.1016/j.jhep.2021.05.026.
|
| [29] |
CHOUDHURY A, JINDAL A, MAIWALL R, et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure(ACLF): Comparison of APASL ACLF research consortium(AARC) and CLIF-SOFA models[J]. Hepatol Int, 2017, 11( 5): 461- 471. DOI: 10.1007/s12072-017-9816-z.
|
| [30] |
O’LEARY JG, REDDY KR, GARCIA-TSAO G, et al. NACSELD acute-on-chronic liver failure(NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis[J]. Hepatology, 2018, 67( 6): 2367- 2374. DOI: 10.1002/hep.29773.
|
| [31] |
GUSTOT T, FERNANDEZ J, GARCIA E, et al. Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis[J]. Hepatology, 2015, 62( 1): 243- 252. DOI: 10.1002/hep.27849.
|
| [32] |
YU ZJ, ZHANG Y, CAO YY, et al. A dynamic prediction model for prognosis of acute-on-chronic liver failure based on the trend of clinical indicators[J]. Sci Rep, 2021, 11( 1): 1810. DOI: 10.1038/s41598-021-81431-0.
|
| [33] |
MENG QH, HOU W, YU HW, et al. Resting energy expenditure and substrate metabolism in patients with acute-on-chronic hepatitis B liver failure[J]. J Clin Gastroenterol, 2011, 45( 5): 456- 461. DOI: 10.1097/MCG.0b013e31820f7f02.
|
| [34] |
CHEUNG K, LEE SS, RAMAN M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition management strategies[J]. Clin Gastroenterol Hepatol, 2012, 10( 2): 117- 125. DOI: 10.1016/j.cgh.2011.08.016.
|
| [35] |
Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association. Clinical guidelines on nutrition in end-stage liver disease[J]. J Clin Hepatol, 2019, 35( 6): 1222- 1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.
中华医学会肝病学分会, 中华医学会消化病学分会. 终末期肝病临床营养指南[J]. 临床肝胆病杂志, 2019, 35( 6): 1222- 1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.
|
| [36] |
YAO J, ZHOU XS, WANG H, et al. Persistently increased resting energy expenditure predicts short-term mortality in patients with acute-on-chronic liver failure[J]. Ann Nutr Metab, 2018, 73( 1): 2- 9. DOI: 10.1159/000487604.
|
| [37] |
LIU X, KONG M, HUA X, et al. Effects of an individualized nutritional intervention on the prognosis of patients with liver failure[J]. Asia Pac J Clin Nutr, 2022, 31( 2): 215- 221. DOI: 10.6133/apjcn.202206_31(2).0007.
|
| [38] |
KUMAR R, PRAKASH SS, PRIYADARSHI RN, et al. Sarcopenia in chronic liver disease: A metabolic perspective[J]. J Clin Transl Hepatol, 2022, 10( 6): 1213- 1222. DOI: 10.14218/JCTH.2022.00239.
|
| [39] |
GREGORY PB, KNAUER CM, KEMPSON RL, et al. Steroid therapy in severe viral hepatitis. A double-blind, randomized trial of methyl-prednisolone versus placebo[J]. N Engl J Med, 1976, 294( 13): 681- 687. DOI: 10.1056/NEJM197603252941301.
|
| [40] |
FUJIWARA K, YASUI S, HAGA Y, et al. Early combination therapy with corticosteroid and nucleoside analogue induces rapid resolution of inflammation in acute liver failure due to transient hepatitis B virus infection[J]. Intern Med, 2018, 57( 11): 1543- 1552. DOI: 10.2169/internalmedicine.9670-17.
|
| [41] |
ZHAO J, ZHANG JY, YU HW, et al. Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy[J]. Cell Mol Immunol, 2012, 9( 5): 417- 422. DOI: 10.1038/cmi.2011.51.
|
| [42] |
HUANG C, YU KK, ZHENG JM, et al. Steroid treatment in patients with acute-on-chronic liver failure precipitated by hepatitis B: A 10-year cohort study in a university hospital in East China[J]. J Dig Dis, 2019, 20( 1): 38- 44. DOI: 10.1111/1751-2980.12691.
|
| [43] |
JIA L, XUE R, ZHU YK, et al. The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: A prospective multi-center clinical trial[J]. BMC Med, 2020, 18( 1): 383. DOI: 10.1186/s12916-020-01814-4.
|
| [44] |
XUE R, MENG QH. The management of glucocorticoid therapy in liver failure[J]. Front Immunol, 2019, 10: 2490. DOI: 10.3389/fimmu.2019.02490.
|
| [45] |
ZACCHERINI G, WEISS E, MOREAU R. Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment[J]. JHEP Rep, 2020, 3( 1): 100176. DOI: 10.1016/j.jhepr.2020.100176.
|
| [46] |
CASULLERAS M, ZHANG IW, LÓPEZ-VICARIO C, et al. Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure[J]. Cells, 2020, 9( 12): 2632. DOI: 10.3390/cells9122632.
|
| [47] |
CHEN P, WANG YY, CHEN C, et al. The immunological roles in acute-on-chronic liver failure: An update[J]. Hepatobiliary Pancreat Dis Int, 2019, 18( 5): 403- 411. DOI: 10.1016/j.hbpd.2019.07.003.
|
| [48] |
XU Y, JIANG YF, LI Y. Outcomes of glucocorticoid treatment in HBVAssociated acute-on-chronic liver failure patients: A retrospective observational study[J]. Turk J Gastroenterol, 2021, 32( 5): 473- 480. DOI: 10.5152/tjg.2021.20257.
|
| [49] |
WU ZB, WANG K, MO ZS, et al. Early, short-term, low-dose glucocorticoid therapy effectively blocks progression of severe acute exacerbation of chronic hepatitis B to liver failure[J]. Clin Res Hepatol Gastroenterol, 2021, 45( 5): 101505. DOI: 10.1016/j.clinre.2020.07.010.
|
| [50] |
SHI P, ZHU WT, LIANG A, et al. Efficacy and predictive factors of glucocorticoid therapy for patients with hepatitis B virus-related acute-on-chronic liver failure[J]. Acta Gastroenterol Belg, 2022, 85( 4): 593- 600. DOI: 10.51821/85.4.10728.
|
| [51] |
Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Expert consensus on clinical application of artificial liver and blood purification(2022 edition)[J]. J Clin Hepatol, 2022, 38( 4): 767- 775. DOI: 10.3969/j.issn.1001-5256.2022.04.007.
中华医学会肝病学分会重型肝病与人工肝学组. 人工肝血液净化技术临床应用专家共识(2022年版)[J]. 临床肝胆病杂志, 2022, 38( 4): 767- 775. DOI: 10.3969/j.issn.1001-5256.2022.04.007.
|
| [52] |
OCAK I. A 15-year retrospective study of supportive extracorporeal therapies including plasma exchange and continuous venovenous hemodiafiltration of 114 adults with acute liver failure awaiting liver transplantation[J]. Ann Transplant, 2023, 28: e939745. DOI: 10.12659/AOT.939745.
|
| [53] |
WANG L, XU WX, ZHU S, et al. Double plasma molecular adsorption system with sequential low-dose plasma exchange in patients with hepatitis B virus-related acute-on-chronic liver failure: A prospective study[J]. J Clin Transl Hepatol, 2023, 11( 4): 908- 917. DOI: 10.14218/JCTH.2022.00254.
|
| [54] |
XU WX, ZHU S, YANG L, et al. Safety and efficacy of double plasma molecular adsorption system with sequential low-volume plasma exchange in intermediate-stage hepatitis B virus-related acute-on-chronic liver failure[J]. J Med Virol, 2023, 95( 3): e28650. DOI: 10.1002/jmv.28650.
|
| [55] |
MAIWALL R, BAJPAI M, SINGH A, et al. Standard-volume plasma exchange improves outcomes in patients with acute liver failure: A randomized controlled trial[J]. Clin Gastroenterol Hepatol, 2022, 20( 4): e831- e854. DOI: 10.1016/j.cgh.2021.01.036.
|
| [56] |
HIRANO R, NAMAZUDA K, HIRATA N. Double filtration plasmapheresis: Review of current clinical applications[J]. Ther Apher Dial, 2021, 25( 2): 145- 151. DOI: 10.1111/1744-9987.13548.
|
| [57] |
LIU H, ZHANG Q, LIU L, et al. Effect of artificial liver support system on short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure[J]. Artif Organs, 2020, 44( 10): E434- E447. DOI: 10.1111/aor.13710.
|
| [58] |
YAO J, LI S, ZHOU L, et al. Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure[J]. J Clin Apher, 2019, 34( 4): 392- 398. DOI: 10.1002/jca.21690.
|
| [59] |
ZHOU L, CHEN Y. Model selection and curative effect judgment criteria for artificial liver in the treatment of liver failure[J]. Chin J Hepatol, 2022, 30( 2): 127- 130. DOI: 10.3760/cma.j.cn501113-20220108-00008.
周莉, 陈煜. 人工肝治疗肝衰竭模式选择及其疗效判断标准[J]. 中华肝脏病杂志, 2022, 30( 2): 127- 130. DOI: 10.3760/cma.j.cn501113-20220108-00008.
|