《2026年欧洲肝病学会意见书:脂肪性肝病临床前模型》摘译
DOI: 10.12449/JCH260908
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:秦静波负责翻译、整理、摘译;杨志云负责文章审校;江宇泳负责文章审校及最终定稿;段浩鑫负责翻译、整理。
An excerpt of the 2026 EASL position paper on preclinical models of steatotic liver disease
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摘要: 脂肪性肝病的病因、代谢背景及病理进程具有显著异质性,单一模型难以完整重现人类疾病。现有临床前模型种类繁多,在命名、模型选择、实验条件及评价指标方面尚需规范。2026年欧洲肝病学会发布意见书,系统评述代谢功能障碍相关脂肪性肝病、代谢功能障碍与酒精相关性肝病及酒精相关性肝病的体内、体外和离体模型,提出依据疾病亚型、研究目的和目标终点选择模型,并对药理学阳性对照、实验设计、组织病理评价及最低报告指标提出建议。本文对该意见书的核心内容进行摘译,为规范脂肪性肝病临床前模型的选择与评价、增强模型与人类疾病表型的一致性提供参考。Abstract: Steatotic liver disease is characterized by substantial heterogeneity in etiology, metabolic background, and pathological progression, and no single model can fully recapitulate the spectrum of human disease. There are currently various preclinical models, yet further standardization is needed in terms of nomenclature, model selection, experimental conditions, and assessment indices. Issued by the European Association for the Study of the Liver, this 2026 position paper systematically reviews the in vivo, in vitro, and ex vivo models of metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and alcohol-associated liver disease, and alcohol-associated liver disease. It proposes the selection of models based on disease subtype, research objective, and target endpoint and provides recommendations for pharmacological positive controls, experimental design, histopathological assessment, and minimum reporting requirements. This article gives an excerpt of the key contents of the position paper, so as to facilitate standardized selection and evaluation of preclinical models for steatotic liver disease and improve their concordance with human disease phenotypes.
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Key words:
- Steatotic Liver Disease /
- Preclinical Models /
- Europe /
- Biological Model
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[1] Gallage S, Castro R E, Estall J, et al. EASL position paper on preclinical models of steatotic liver disease[J]. J Hepatol, 2026, 85( 2): 345- 382. DOI: 10.1016/j.jhep.2026.04.029. -

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