肝脏疾病合并溶血性贫血的研究进展
DOI: 10.12449/JCH260905
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:王谦负责文献收集、论文框架设计和初稿撰写;孔明负责写作思路拟定、重要学术内容核校、全文修订和最终定稿。
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摘要: 肝脏疾病与溶血性贫血存在双向联系。肝脏病变可通过红细胞膜脂质异常、铜毒性作用、氧化应激、机械损伤、免疫异常等机制,诱发或促进红细胞破坏;部分原发性溶血性疾病可因黄疸、胆色素结石、脾大或腹腔静脉血栓形成,首先表现为肝胆系统异常。根据红细胞主要破坏部位,溶血可分为血管内溶血和血管外溶血,但二者并非相互排斥,且可随疾病阶段和治疗情况发生变化。肝豆状核变性急性肝衰竭相关溶血、阵发性睡眠性血红蛋白尿及部分经颈静脉肝内门体分流术术后溶血以血管内破坏为主要特征;棘状细胞贫血、遗传性红细胞膜病和温抗体型自身免疫性溶血性贫血以血管外破坏为主;Zieve综合征、葡萄糖-6-磷酸脱氢酶缺乏症、部分自身免疫性溶血及肝移植术后过客淋巴细胞综合征可兼有两种溶血途径。本文以溶血的发生部位为核心框架,以免疫机制和非免疫机制为补充,综述肝病相关溶血及可表现为肝胆异常的原发性溶血性疾病,并提出分层诊断和病因导向的治疗路径。Abstract: There is a bidirectional relationship between liver diseases and hemolytic anemia. Liver diseases may cause or aggravate erythrocyte destruction through abnormalities in erythrocyte membrane lipids, copper toxicity, oxidative stress, mechanical injury, and immune dysregulation; conversely, some primary hemolytic diseases may initially present with abnormalities in the hepatobiliary system due to jaundice, bile pigment stones, splenomegaly, or thrombosis of the splanchnic veins. Hemolysis is classified into intravascular hemolysis and extravascular hemolysis according to the predominant site of erythrocyte destruction; however, the two processes may coexist and may change with disease stage or treatment. Hemolysis associated with Wilson’s disease and acute liver failure, paroxysmal nocturnal hemoglobinuria, and some cases of hemolysis after transjugular intrahepatic portosystemic shunt are characterized by intravascular destruction; spur cell anemia, hereditary erythrocyte membrane disorders, and warm-antibody autoimmune hemolytic anemia are mainly characterized by extravascular destruction; Zieve syndrome, glucose-6-phosphate dehydrogenase deficiency, some cases of autoimmune hemolytic anemia, and passenger lymphocyte syndrome after liver transplantation may involve both pathways of hemolysis. With the site of hemolysis as the primary framework and the immune versus non-immune mechanisms as a supplementation, this article reviews hemolysis associated with liver diseases and primary hemolytic disorders that may present with hepatobiliary abnormalities and proposes a therapeutic approach based on stratified diagnosis and etiology.
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Key words:
- Liver Diseases /
- Anemia, Hemolytic /
- Hemolysis
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