髓系细胞触发受体2介导的巨噬细胞在肝脏疾病中的双向作用

李思淼; 徐加敏; 冯阳; 唐映梅

doi:10.12449/JCH260531

髓系细胞触发受体2介导的巨噬细胞在肝脏疾病中的双向作用

DOI: 10.12449/JCH260531

昆明医科大学第二附属医院消化内科，昆明 650000

基金项目:

国家自然科学基金 (82360108);

云南省陈洁专家工作站 (202305AF150065);

云南省医学领军人才 (L-2019013);

昆明医科大学硕士研究生创新基金 (2025S098)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李思淼负责文章的构思与设计，起草论文；徐加敏和冯阳负责文章修改；唐映梅负责最终版本修订。

详细信息

通信作者:
唐映梅， tangyingmei_med@kmmu.edu.cn （ORCID： 0000-0002-0731-4198）

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出版历程
- 收稿日期: 2025-07-31
- 录用日期: 2025-10-20
- 出版日期: 2026-05-20

Bidirectional role of triggering receptor expressed on myeloid cells 2-mediated macrophages in liver diseases

Department of Gastroenterology，The Second Affiliated Hospital of Kunming Medical University，Kunming 650000，China

Research funding:

National Natural Science Foundation of China (82360108);

Chen Jie Expert Workstation in Yunnan Province (202305AF150065);

Leading Medical Talents in Yunnan Province (L-2019013);

Kunming Medical University Master’s Research Innovation Fund (2025S098)

More Information

Corresponding author: TANG Yingmei， tangyingmei_med@kmmu.edu.cn （ORCID： 0000-0002-0731-4198）

摘要

摘要: 髓系细胞触发受体2（TREM2）作为免疫调节的关键受体，在肝脏疾病的发生和发展中发挥重要作用，但其在不同肝脏疾病类型及不同阶段的具体作用机制与调控策略仍需系统梳理。本文系统综述了TREM2的分子特征与信号通路，阐述了TREM2⁺巨噬细胞在脂质代谢、吞噬功能、炎症反应及纤维化中的多重功能，并重点分析了TREM2在不同肝脏疾病中的动态与双向作用。靶向TREM2信号轴有望成为调节肝脏免疫微环境、干预疾病进展的新策略。
- 肝疾病 /
- 髓系细胞触发受体2 /
- 巨噬细胞 /
- 免疫
Abstract: As a key receptor for immune regulation， triggering receptor expressed on myeloid cells 2 （TREM2） plays an important role in the development and progression of liver diseases， but its specific mechanisms and regulatory strategies in different types and stages of liver diseases remain to be systematically elucidated. This article systematically reviews the molecular characteristics and signaling pathways of TREM2， elaborates on the multiple functions of TREM2⁺ macrophages in lipid metabolism， phagocytic function， inflammatory response， and fibrosis， and analyzes the dynamic and bidirectional roles of TREM2 in different liver diseases. Targeting the TREM2 signaling axis is expected to become a new strategy for regulating the hepatic immune microenvironment and intervening in disease progression.
- Liver Diseases /
- Triggering Receptor Expressed on Myeloid Cells 2 /
- Macrophages /
- Immunity

HTML全文

注： TNF-α，肿瘤坏死因子α；IL-1β，白细胞介素1β；ROS，活性氧；IFN-β，干扰素β；IL-10，白细胞介素10；HSC，肝星状细胞；MMP，基质金属蛋白酶；HCC，肝细胞癌；TLR，Toll样受体；PI3K-Akt，磷脂酰肌醇3激酶-蛋白激酶B；miR-106b-5p，微小核糖核酸-106b-5p；TREM2，髓系细胞触发受体2；sTREM2，可溶性髓系细胞触发受体2。

图 1 TREM2在肝脏疾病中的作用

Figure 1. Role of TREM2 in liver diseases

下载: 全尺寸图片幻灯片

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