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代谢功能障碍与酒精相关性肝病：新概念与新进展
DOI: 10.12449/JCH260426
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：林儒焘负责设计论文框架，起草论文；徐斐负责数据收集，论文修改；辛鑫负责论文修改；胡义扬及冯琴负责拟定写作思路，指导撰写文章并最后定稿。林儒焘和徐斐为共同第一作者。
Metabolic-dysfunction and alcohol-associated liver disease： A new concept and recent advances
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摘要: 2023年，国际多学会提出了“代谢功能障碍与酒精相关性肝病（MetALD）”这一概念，用以指代同时存在代谢功能障碍和中等量饮酒的脂肪肝人群。近年来，该领域的证据体系正迅速发展与完善。本文综述了MetALD的背景与定义、流行病学特征及自然史、临床表型、诊断评估方法以及治疗研究的最新进展，并对未来的研究方向进行展望。
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关键词:
- 代谢功能障碍与酒精相关性肝病 /
- 代谢相关脂肪性肝病 /
- 酒精性肝病
Abstract: In 2023， multiple international societies proposed the concept of metabolic-dysfunction and alcohol-associated liver disease （MetALD） to characterize patients with steatotic liver disease who exhibit metabolic dysfunction and consume alcohol at a moderate level. In recent years， the evidence system in this field has been constantly developed and improved. This article reviews the latest research advances in MetALD from the aspects of background， definition， epidemiological characteristics， natural history， clinical phenotype， diagnostic and assessment methods， and treatment regimens， as well as the directions for future investigation. -
注： PEth，磷脂酰乙醇；MAFLD，代谢相关脂肪性肝病；MetALD，代谢功能障碍与酒精相关性肝病；ALD，酒精性肝病。本图改编自文献［ 35］，经授权许可使用，许可号：6086371097660。
图 1 应用自报饮酒与PEth结果及其他临床信息综合判断脂肪肝亚型
Figure 1. Comprehensive determination of steatotic liver disease subtypes using self-reported alcohol consumption and PEth results as well as other clinical information
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