原发性胆汁性胆管炎患者生活质量影响因素的系统评价

方艳秋; 贾桂; 崔丽娜; 尚玉龙; 韩英

doi:10.12449/JCH251016

原发性胆汁性胆管炎患者生活质量影响因素的系统评价

DOI: 10.12449/JCH251016

空军军医大学第一附属医院消化内科，西安 710032

基金项目:

国家自然科学基金 (82270551)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：方艳秋负责设计论文框架，数据收集，统计学处理并起草论文；贾桂负责数据收集，统计学处理并绘制图表；崔丽娜、尚玉龙负责数据收集，论文修改；韩英负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
韩英， hanying@fmmu.edu.cn （ORCID： 0000-0003-3046-9507）

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出版历程
- 收稿日期: 2025-03-24
- 录用日期: 2025-06-09
- 出版日期: 2025-10-25

Influencing factors for quality of life in patients with primary biliary cholangitis： A systematic review

Department of Gastroenterology，The First Affiliated Hospital of Air Force Medical University，Xi’an 710032，China

Research funding:

National Natural Science Foundation of China (82270551)

More Information

Corresponding author: HAN Ying， hanying@fmmu.edu.cn （ORCID： 0000-0003-3046-9507）

摘要

摘要: 目的通过系统评价，为理解影响原发性胆汁性胆管炎患者生活质量的核心要素提供循证基础。方法检索知网、万方、中国生物医学文献数据库、维普、PubMed、Embase、Web of Science、Ovid、Scopus、Medline数据库，检索时间为建库至2025年1月11日，纳入利用PBC-40量表评估原发性胆汁性胆管炎患者生活质量影响因素的文献，采用美国卫生保健质量研究机构编制量表进行质量评价后，定性评价纳入研究基本情况。结果共纳入11篇文献，结果显示年龄、性别、Alb、ALP、GGT、DBil、TBil、TBA、ALT、AST、BMI及HDL-C是原发性胆汁性胆管炎患者生活质量的重要影响因素。结论影响因素包括人口学特征、肝功能相关指标、体格及代谢指标等三方面，但文献数量有限，未来仍需要更多高质量、大样本的研究。
- 原发性胆汁性胆管炎 /
- 生活质量 /
- 影响因素分析 /
- 系统评价
Abstract: Objective To investigate the core influencing factors for quality of life in patients with primary biliary cholangitis through a systematic review， and to provide an evidence-based basis for understanding such factors. Methods The databases including CNKI， Wanfang Data， CBM， VIP， PubMed， Embase， Web of Science， Ovid， Scopus， and Medline were searched for articles assessing the influencing factors for quality of life in patients with primary biliary cholangitis using PBC-40 scale published up to January 11， 2025. Quality assessment was conducted using the scale compiled by the Agency for Healthcare Research and Quality， and then a qualitative evaluation was performed for the basic situation of the studies included in the analysis. Results A total of 11 articles were included， and the results showed that age， sex， albumin， alkaline phosphatase， gamma-glutamyl transferase， direct bilirubin， total bilirubin， total bile acid， alanine aminotransferase， aspartate aminotransferase， body mass index， and high-density lipoprotein cholesterol were important influencing factors for quality of life in patients with primary biliary cholangitis. Conclusion Influencing factors include demographic features， liver function parameters， and physical and metabolic indicators； however， due to the limited number of studies， more high-quality large-sample studies are needed in the future.
- Primary Biliary Cholangitis /
- Quality of Life /
- Root Cause Analysis /
- Systematic Review

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图 1 文献筛选流程

Figure 1. Literature screening process

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表 1 文献检索策略

Table 1. Strategy for searching literature

步骤	检索式
#1	“liver cirrhosis， biliary”［MeSH Terms］ OR （“primary biliary cholangitis”［Title/Abstract］ OR “PBC”［Title/Abstract］）
#2	“Quality of Life”［MeSH Terms］ OR （“health relate* quality of life”［Title/Abstract］ OR “QoL”［Title/Abstract］ OR “HRQoL” ［Title/Abstract］ OR “life quality”［Title/Abstract］ OR “HRQL”［Title/Abstract］ OR “wellbeing”［Title/Abstract］ OR “well being”［Title/Abstract］）
#3	#1 AND #2

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表 2 纳入文献的基本特征及质量评价结果

Table 2. Basic characteristics of included literature and results of quality evaluation

第一作者	年份	国家	样本量（例）	研究类型	影响因素	质量评分（分）
Dyson^［12］	2016	英国	2 055	横断面研究	年龄	9
Raszeja- Wyszomirska^［20］	2016	波兰	205	横断面研究	肝硬化、性别、gp210自身抗体、AMA	8
Yagi^［14］	2018	日本	496	横断面研究	年龄、性别、随访时间、事件存在、服用UDCA、 Alb、ALT、ALP、AST、TBil	6
张硕^［13］	2018	中国	65	横断面研究	ALT、ALP、AST、GGT、DBil、TBil、TBA	7
Kaps^［15］	2019	德国	140	横断面研究	HDL-C、IgG	9
Milovanovic^［16］	2020	塞尔维亚	130	横断面研究	Alb、ALP、GGT、Mayo评分、疾病严重程度	9
贾桂^［21］	2020	中国	37	横断面研究	年龄、BMI、ALP、GGT、抗着丝点抗体	8
Liu^［17］	2021	中国	383	横断面研究	年龄、性别、BMI、Alb、ALT、AST、TBil、PLT	9
聂伟杰^［22］	2021	中国	78	横断面研究	ALT、ALP、AST、GGT、DBil、TBil、IBil、TBA	9
杨娴^［18］	2022	中国	60	横断面研究	Alb、DBil、TBil、TBA、HDL-C、PT、TP、TC、RBC、ChE、Hb	6
刘曼^［19］	2022	中国	56	横断面研究	焦虑、抑郁、Alb、TBil	9
注：AMA，抗线粒体抗体；UDCA，熊去氧胆酸；TBA，总胆汁酸；TP，血清总蛋白；ChE，胆碱酯酶。

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