酒精性肝病增加脓毒症易感性机制的研究进展

刘航; 郭焱

doi:10.12449/JCH250829

酒精性肝病增加脓毒症易感性机制的研究进展

DOI: 10.12449/JCH250829

刘航¹,
郭焱^2, , ,

1.
山西医科大学第一临床医学院，太原 030001
2.
山西医科大学第一医院重症医学科，太原 030001

基金项目:

山西省留学回国人员科技活动择优资助项目 (20240045)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：郭焱负责课题设计，指导撰写文章并最后定稿；刘航负责资料收集分析，撰写论文。

详细信息

通信作者:
郭焱， 2008guoyan@sina.com （ORCID： 0009-0003-9176-0637）

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- 被引次数: 0
出版历程
- 收稿日期: 2025-01-05
- 录用日期: 2025-03-10
- 出版日期: 2025-08-25

Research advances in the mechanisms of increased susceptibility to sepsis in alcoholic liver disease

Hang LIU¹,
Yan GUO^{2
, ,
,}

1.
The First Clinical College of Shanxi Medical University，Taiyuan 030001，China
2.
Department of Critical Care Medicine，The First Hospital of Shanxi Medical University，Taiyuan 030001，China

Research funding:

Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province (20240045)

More Information

Corresponding author: GUO Yan， 2008guoyan@sina.com （ORCID： 0009-0003-9176-0637）

摘要

摘要: 脓毒症是由宿主对感染的反应失调导致危及生命的器官功能障碍，目前尚缺乏有效的治疗方法。酒精性肝病（ALD）是西方国家酒精导致死亡的最重要原因。脓毒症是ALD最常见的并发症和死亡原因之一，本文对ALD增加脓毒症易感性机制的研究进展进行综述，旨在为ALD致脓毒症患者的预防和治疗提供参考。
- 脓毒症 /
- 酒精性肝病 /
- 免疫系统 /
- 胃肠道微生物组
Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection， and currently there is still a lack of effective therapies. Alcoholic liver disease （ALD） is the most important cause of death caused by alcohol in Western countries， and sepsis is one of the most common complications and causes of death in ALD. This article reviews the research advances in the mechanism by which ALD increases the susceptibility to sepsis， in order to provide a reference for the prevention and treatment of sepsis in ALD patients.
- Sepsis /
- Alcoholic Liver Disease /
- Immune System /
- Gastrointestinal Microbiome

HTML全文

注： CRIg，免疫球蛋白超家族补体受体；NET，中性粒细胞胞外陷阱；Th1，辅助性T淋巴细胞1型；Treg，调节性T淋巴细胞；SIgA，分泌型免疫球蛋白A。

图 1 ALD增加脓毒症易感性的机制

Figure 1. Mechanisms by which alcoholic liver disease increases susceptibility to sepsis

下载: 全尺寸图片幻灯片

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