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PINK1/Parkin信号通路介导的线粒体自噬在代谢相关脂肪性肝病中的作用及靶向治疗研究进展
DOI: 10.12449/JCH250828
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：朱胜金负责撰写论文；朱小灯、李开楊负责设计论文框架及指导撰写文章并最后定稿；杨梅、吴娴负责论文修改。
Role of mitophagy induced by the PTEN-induced kinase 1/Parkin signaling pathway in metabolic associated fatty liver disease and related advances in targeted therapies
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摘要: 代谢相关脂肪性肝病（MAFLD）发病机制复杂，而线粒体自噬参与了MAFLD的发生发展，在肝脏代谢途径和信号网络中起着关键作用。线粒体自噬受多种途径的调控，同源性磷酸酶张力蛋白诱导激酶1（PINK1）/帕金蛋白（Parkin）途径被认为是调节线粒体自噬的主要途径，PINK1/Parkin介导的线粒体自噬可调节脂质代谢、炎症及纤维化，缓解MAFLD的进展。本文综述了PINK1/Parkin介导的线粒体自噬在MAFLD中的作用及靶向治疗的研究进展，以期为防治MAFLD提供理论依据和思路。
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关键词:
- 代谢相关脂肪性肝病 /
- 线粒体自噬 /
- PINK1/Parkin信号通路
Abstract: Metabolic associated fatty liver disease （MAFLD） has a complex pathogenesis， and mitophagy is involved in the development and progression of MAFLD and plays a key role in liver metabolic pathways and signaling networks. Mitophagy is regulated by a variety of pathways， and the PTEN-induced kinase 1 （PINK1）/Parkin pathway is considered the main pathway for regulating mitophagy. Mitophagy mediated by the PINK1/Parkin pathway can regulate lipid metabolism， inflammation， and fibrosis and delay the progression of MAFLD. This article reviews the role of mitophagy mediated by the PINK1/Parkin pathway in MAFLD and the research advances in targeted therapy， in order to provide theoretical bases and ideas for the prevention and treatment of MAFLD. -
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