联合肝脏分隔和门静脉结扎的二步肝切除术（ALPPS）与肝癌

周俭; 王征

doi:10.12449/JCH250802

联合肝脏分隔和门静脉结扎的二步肝切除术（ALPPS）与肝癌

DOI: 10.12449/JCH250802

周俭^, ,,
王征

复旦大学附属中山医院肝胆肿瘤和肝移植外科，上海 200032

基金项目:

国家自然科学基金专家推荐类原创探索计划 (82150004)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：周俭负责论文设计，拟定写作思路，指导撰写文章并最后定稿；王征负责撰写论文。

详细信息

通信作者:
周俭， zhou.jian@zs-hospital.sh.cn （ORCID： 0000-0002-2118-1117）

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出版历程
- 收稿日期: 2025-06-18
- 录用日期: 2025-06-30
- 出版日期: 2025-08-25

Associating liver partition and portal vein ligation for staged hepatectomy and liver cancer

Jian ZHOU^{,
,},
Zheng WANG

Department of Hepatobiliary Surgery and Liver Transplantation，Zhongshan Hospital，Fudan University，Shanghai 200032，China

Research funding:

National Natural Science Foundation of China Expert-Recommended Original Exploration Program (82150004)

More Information

Corresponding author: ZHOU Jian， zhou.jian@zs-hospital.sh.cn （ORCID： 0000-0002-2118-1117）

摘要

摘要: 联合肝脏分隔和门静脉结扎的二步肝切除术（ALPPS）是肝脏外科突破性的创新技术，提高了Ⅰ期无法手术切除巨大/多发肝癌的手术切除率。ALPPS手术方式的不断改进，进一步提高了手术的安全性。与系统治疗、局部治疗导致的肿瘤学转化相比，在手术切除成功率、间隔时间方面，ALPPS具有显著优势。未来研究应重点关注ALPPS术后患者的长期肿瘤学预后和生活质量评估。
- 肝肿瘤 /
- 联合肝脏分隔和门静脉结扎的二步肝切除术 /
- 治疗学
Abstract: Associating liver partition and portal vein ligation for staged hepatectomy （ALPPS） is a groundbreaking and innovative technique in the field of liver surgery， and it has significantly increased the resection rate of large or multifocal liver cancer that cannot be resected in stage Ⅰ surgery. Continuous improvements in the ALPPS surgical procedure have further enhanced surgical safety. Compared with systemic therapy and local treatment for oncological conversion， ALPPS has notable advantages in the success rate of surgical resection and the time interval required for the procedure. Future research will focus on the long-term oncological outcomes and quality of life of patients after ALPPS.
- Liver Neoplasms /
- Associating Liver Partition And Portal Vein Ligation For Staged Hepatectomy /
- Therapeutics

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注： Ⅰ期手术，结扎门静脉右支，同时行肝实质离断；Ⅱ期手术，在FLR增生达到安全标准后行再次手术，切除肿瘤。

图 1 ALPPS手术示意图

Figure 1. Schematic diagram of liver partition and portal vein ligation for staged hepatectomy

下载: 全尺寸图片幻灯片

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