吲哚菁绿荧光显像技术在胆道闭锁中的应用

李翰林; 何钰铭; 罗子懿; 徐晓钢

doi:10.12449/JCH250635

吲哚菁绿荧光显像技术在胆道闭锁中的应用

DOI: 10.12449/JCH250635

李翰林^{1, 2},
何钰铭²,
罗子懿²,
徐晓钢^1, , ,

1.
广州医科大学附属妇女儿童医疗中心，广州 510620
2.
广州医科大学儿科学院，广州 510180

基金项目:

广州市卫生健康科技项目 (20231A011040);

广州医学院科研基金项目 (2023ekky007)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李翰林负责对文章思路的设计、论文的撰写及修改；何钰铭、罗子懿负责查阅相关文献及论文的撰写和修改；徐晓钢负责指导修改论文及最后定稿。

详细信息

通信作者:
徐晓钢， xiaogang410428700@163.com （ORCID： 0000-0001-9048-3437）

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出版历程
- 收稿日期: 2024-10-23
- 录用日期: 2025-02-11
- 出版日期: 2025-06-25

Application of indocyanine green fluorescence imaging technology in biliary atresia

Hanlin LI^{1, 2},
Yuming HE²,
Ziyi LUO²,
Xiaogang XU^{1
, ,
,}

1.
Guangzhou Women and Children’s Medical Center，Guangzhou Medical University，Guangzhou 510620，China
2.
School of Pediatrics，Guangzhou Medical University，Guangzhou 510180，China

Research funding:

Guangzhou Municipal Health Science and Technology Project (20231A011040);

Research Fund of Guangzhou Medical University (2023ekky007)

More Information

Corresponding author: XU Xiaogang， xiaogang410428700@163.com （ORCID： 0000-0001-9048-3437）

摘要

摘要: 胆道闭锁的特征是进行性炎症和胆管纤维阻塞，最终导致胆汁淤积性肝硬化。Kasai手术是治疗胆道闭锁的标准术式，早期诊断是影响胆道闭锁预后的关键因素。吲哚菁绿是一种近红外光敏染料，静脉注射后可被肝细胞有效地选择性吸收，以游离形式经胆汁分泌入肠道随粪便排出，具有极高的安全性。此外，吲哚菁绿可在近红外光下发出荧光，这些荧光可以被摄像仪器捕获并转换为视觉图像，吲哚菁绿荧光显像技术可以实时反映术中情况，显著提高手术成功率。本文对近年来吲哚菁绿在术前早期诊断、术中造影和术后肝功能评估中的应用进展进行综述。
- 胆道闭锁 /
- 吲哚花青绿 /
- 早期诊断
Abstract: Biliary atresia （BA） is characterized by progressive inflammation and fibrous obstruction of bile ducts， ultimately leading to cholestatic liver cirrhosis. Kasai surgery is the standard procedure for the treatment of BA， and early diagnosis is a key influencing factor for the prognosis of BA. Indocyanine green （ICG） is a near-infrared photosensitive dye that is efficiently and selectively absorbed by hepatocytes after intravenous injection， and it enters the intestine via bile and is excreted with the feces in the free form， with a favorable safety profile. In addition， ICG can emit fluorescence under near-infrared light， which can be captured by camera instruments and converted into visual images， and ICG fluorescence imaging technology can reflect the intraoperative situation in real time and significantly improve the success rate of the surgical procedure. This article reviews the advances in the application of ICG in early preoperative diagnosis， intraoperative imaging， and postoperative liver function assessment in recent years.
- Biliary Atresia /
- Indocyanine Green /
- Early Diagnosis

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参考文献(52)

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