代谢组学在中医药防治肝衰竭中的应用进展

胡梦玲; 李炯汾; 曾阳玲; 张日云; 毛德文

doi:10.12449/JCH250631

代谢组学在中医药防治肝衰竭中的应用进展

DOI: 10.12449/JCH250631

1.
广西中医药大学研究生院，南宁 530001
2.
广西中医药大学第一附属医院肝病科，南宁 530023

基金项目:

国家自然科学基金 (82360912);

国家自然科学基金 (81960841);

国家自然科学基金 (82274434);

广西自然科学基金 (2023GXNSFBA026190);

广西中医药大学博士科研启动基金 (2021BS028);

广西高校中青年教师科研基础能力提升项目 (2022KY0299);

广西中医药大学第一附属医院科研项目 (2021QN004)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：胡梦玲负责课题设计，资料分析，撰写论文；李炯汾、曾阳玲、张日云参与收集数据，修改论文；毛德文负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
毛德文， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

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- 文章访问数: 440
- HTML全文浏览量: 157
- PDF下载量: 20
- 被引次数: 0
出版历程
- 收稿日期: 2024-09-04
- 录用日期: 2024-11-29
- 出版日期: 2025-06-25

Progress on the application of metabolomics in the prevention and treatment of liver failure using traditional Chinese medicine

1.
Graduate School，Guangxi University of Chinese Medicine，Nanning 530001，China
2.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (82360912);

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82274434);

Guangxi Natural Science Foundation (2023GXNSFBA026190);

Guangxi University of Traditional Chinese Medicine Doctoral Research Foundation (2021BS028);

Guangxi University of Traditional Chinese Medicine Young Teachers’ Scientific Research Foundation Ability Improvement Project (2022KY0299);

The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine Scientific Research Project (2021QN004)

More Information

Corresponding author: MAO Dewen， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

摘要

摘要: 随着中医药和代谢组学在肝衰竭诊疗中的同步发展，依靠磁共振、质谱、色谱技术、代谢流分析、生物信息学等技术，可以定性或定量分析肝衰竭动物模型和患者体内的内源性小分子代谢产物，并找到特定的生物标志物，以便于早期诊断和临床干预。本文对近年来代谢组学在肝衰竭早期诊断、生物标志物的发现、中医证候的鉴别以及中医药治疗方面的应用研究进展进行综述，以期为肝衰竭的中医药诊疗提供依据。
- 肝功能衰竭 /
- 代谢组学 /
- 生物标记 /
- 中医药疗法
Abstract: With the concurrent development of traditional Chinese medicine （TCM） and metabolomics in the diagnosis and treatment of liver failure， techniques such as nuclear magnetic resonance， mass spectrometry， chromatography， metabolic flux analysis， and bioinformatics enable the qualitative or quantitative analysis of endogenous small molecule metabolites in animal models of liver failure and patients with liver failure. These methods help identify specific biomarkers for early diagnosis and clinical intervention. This article reviews recent advancements in metabolomics for the early diagnosis of liver failure， biomarker discovery， identification of TCM syndromes， and the application of TCM in treating liver failure， aiming to provide a basis for TCM-based diagnosis and treatment of liver failure.
- Liver Failure /
- Metabolomics /
- Biomarkers /
- Traditional Chinese Medicine Therapy

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参考文献(42)

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