乙型肝炎病毒基因整合对功能性治愈的影响

俞晓琦; 张欣欣

doi:10.12449/JCH250104

乙型肝炎病毒基因整合对功能性治愈的影响

DOI: 10.12449/JCH250104

俞晓琦,
张欣欣^, ,

上海交通大学医学院附属瑞金医院感染科，临床病毒研究室，上海 200025

基金项目:

国家自然科学基金青年项目 (82402601);

上海市自然科学基金面上项目 (24ZR1448400)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：俞晓琦负责查阅文献和文章撰写；张欣欣负责文章审核并最终定稿。

详细信息

通信作者:
张欣欣， zhangx@shsmu.edu.cn （ORCID： 0000-0002-0598-6425）

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出版历程
- 收稿日期: 2024-11-19
- 录用日期: 2024-12-17
- 出版日期: 2025-01-25

Effect of hepatitis B virus integration on functional cure

Xiaoqi YU,
Xinxin ZHANG^{,
,}

Research Laboratory of Clinical Virology，Department of Infectious Diseases，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

Research funding:

National Natural Science Foundation of China Young Scientist Fund (82402601);

General Project of Natural Science Foundation of Shanghai (24ZR1448400)

More Information

Corresponding author: ZHANG Xinxin， zhangx@shsmu.edu.cn （ORCID： 0000-0002-0598-6425）

摘要

摘要: 功能性治愈是目前国内外慢性乙型肝炎防治指南推荐的理想治疗目标，被定义为完成有限疗程治疗后，血清HBsAg和HBV DNA持续检测不到、HBeAg阴转、伴或不伴HBsAg血清学转换、肝脏炎症缓解和组织病理学改善、终末期肝病发生率显著降低。HBV可以整合到宿主基因组中持续表达HBsAg，且可发生在慢性HBV感染的早期阶段，因此除了肝组织内难以清除的共价闭合环状DNA外，独立于病毒复制的HBV整合来源的HBsAg可能是慢性乙型肝炎患者在抗病毒治疗后难以实现功能性治愈的重要因素。本文围绕近年来HBV整合方面的研究进展，着重探讨其对功能性治愈的影响。
- 乙型肝炎病毒 /
- 基因 /
- 功能性治愈 /
- 抗病毒治疗
Abstract: Functional cure is currently recommended by guidelines as the ideal treatment goal for the prevention and treatment of chronic hepatitis B （CHB） in China and globally， and it is defined as sustained and undetectable serum HBsAg and HBV DNA， HBeAg clearance， and presence or absence of HBsAg seroconversion， accompanied by resolution of liver inflammation， histopathological improvements， and a significant reduction in the incidence rate of end-stage liver disease. HBV can integrate into the host genome and contribute to the continuous production of HBsAg， which can occur in the early stage of chronic HBV infection. In addition to the covalently closed circular DNA that is hard to be eliminated in liver tissue， HBsAg derived from HBV integration independent of viral replication may be the most important factor for the difficulty in achieving functional cure after antiviral therapy in patients with hepatitis B. This article reviews the research advances in HBV integration in recent years and discusses its impact on functional cure.
- Hepatitis B Virus /
- Genes /
- Functional Cure /
- Antiviral Therapy

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参考文献(49)

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