Abstract: To study the changes of red cell nature-immune-adhesion activity (RNIAA) in hepatocirrhosis patients, and investigate the significance of RNIAA in judging the severity of cirrhosis. RNIAA had been used in 40 cases of hepatocirrhosis before treatment, 15days and 30 days after treatment. ALB, TBil, CHE, PT/PTA, but CHE, PT/PTA and the scores of the severity of patient were also analyzed at the same time. RNIAA decreased when the illness being aggravated and increased when the disease recovery, but CHE, PT/PTA were insistent no exactly change. There was a good relationship between RNIAA and the severity of cirrhosis (r=0.74) . The changes of RNIAA in cirrhosis were more sensitive than that of CHE, PT/PTA in short time. It is an important index to reflect the severity of liver function in clinic.